Bupropion, which is an atypical antidepressant, also helps those looking to stop smoking. Although the exact mechanism of how Bupropion helps people quit smoking is not fully understood, it is believed to work through the following actions:
Dopamine and Norepinephrine Reuptake Inhibition: Bupropion inhibits the reuptake of two important neurotransmitters in the brain: dopamine and norepinephrine. By blocking their reabsorption, Bupropion increases the levels of these neurotransmitters in the brain, leading to improved mood and increased alertness, which may help reduce the urge to smoke.
Nicotine Receptor Modulation: Nicotine, the addictive component in cigarettes, binds to specific receptors in the brain known as nicotinic acetylcholine receptors. Bupropion is thought to partially stimulate these receptors in a way that is different from nicotine, which may help reduce nicotine cravings and withdrawal symptoms.
Reduced Withdrawal Symptoms: Bupropion may alleviate some of the withdrawal symptoms associated with quitting smoking, such as irritability, restlessness, and difficulty concentrating. This can make it easier for individuals to cope with the challenges of quitting.